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    Sandoz to commercialize Rizmoic to treat opioid-induced constipation

    Farhat NasimWritten by Farhat Nasim Published On 2019-04-13T09:21:47+05:30  |  Updated On 16 Aug 2021 12:23 PM IST

    HOLZKIRCHEN: Sandoz recently announces that it has signed an agreement with Shionogi & Co Ltd for commercialization of Rizmoic (naldemedine) in the key European markets of Germany, the UK and the Netherlands, plus right of first refusal for certain other European markets.


    Rizmoic, a once-daily 200-microgram oral tablet discovered and developed by Shionogi, is an innovative medicine indicated to treat opioid-induced constipation (OIC) in adult patients previously treated with a laxative. Shionogi announced on February 22, 2019 that it had received EU marketing authorization for Rizmoic.


    OIC is a prevalent and distressing side-effect of opioid therapy that does not respond reliably to treatment with conventional laxatives.


    "Our purpose at Sandoz is to pioneer access by focusing increasingly on differentiated, value-added therapeutics that can make a real difference when it comes to meeting unmet medical needs," said Francesco Balestrieri, Sandoz CEO.


    He added: "This agreement represents a significant step forward for that strategy and for patients in Europe, reinforcing our long-term commitment to building a leading anti-pain franchise and complementing our portfolio dedicated to minimizing the side-effects of opioid use."


    Sandoz has a strong presence in the European market for anti-pain therapeutics, as well as a complementary strategic focus on innovative therapeutic alternatives to combat opioid dependency. This year saw the US launch of two such products, including the first prescription digital therapeutic in this field.


    Under the terms of the agreement, Sandoz will be responsible for commercializing Rizmoic® in Germany, the UK and the Netherlands and Shionogi will be responsible for its manufacturing and development. Further details of the deal are not being disclosed.


    Naldemedine is a peripherally-acting mu-opioid receptor antagonist (PAMORA) that has been developed by Shionogi as a once-daily treatment for OIC. The efficacy and safety of naldemedine have been evaluated in randomized, double-blind, placebo-controlled studies in adult OIC patients in different countries who have chronic non-cancer pain or cancer.


    OIC is a change in bowel movements caused by opioid therapy that is characterized by any of the following: reduced bowel movement frequency, development or worsening of straining to pass bowel movements, a sense of incomplete rectal evacuation, or harder stool consistency.


    Also Read: Sandoz launches generic Treprostinil Injection



    cancercommercializationconstipationEuropean marketsLaxativemedicinesnaldemedineNetherlandsopioid induced constipationopioid therapypharmapharma newsRizmoicSandozShionogi & Co LtdUK

    Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

    Farhat Nasim
    Farhat Nasim

      Farhat Nasim joined Medical Dialogue an Editor for the Business Section in 2017. She Covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She is a graduate of St.Xavier’s College Ranchi. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751 To know about our editorial team click here

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