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    • Johnson and Johnson...

    Johnson and Johnson arm Janssen to discontinue Hepatitis C development program

    Written by Ruby Khatun Khatun Published On 2017-09-14T10:02:00+05:30  |  Updated On 18 Aug 2021 3:26 PM IST

    CORK, Ireland: Janssen Sciences Ireland UC (Janssen), announced a strategic decision to discontinue further development of the investigational hepatitis C treatment regimen JNJ-4178, a combination of three direct acting antivirals - AL-335, odalasvir, and simeprevir.


    The ongoing phase II studies with JNJ-4178 will be completed as planned, but there will be no additional development thereafter. This decision was made in light of the increasing availability of a number of highly effective therapies addressing the medical need for hepatitis C.


    "Going forward, our hepatitis R&D efforts will focus on chronic hepatitis B, where a high unmet medical need still exists. Our scientists are energized by this challenge and our research ambition is to achieve a functional cure for hepatitis B which affects over a quarter of a billion people globally," said Lawrence M. Blatt, Ph.D., Global Therapeutic Area Head, Infectious Disease Therapeutics, Janssen.


    "At Janssen, we focus our research and development on areas of greatest unmet medical need where we can combine our excellent internal science with the best available external innovation to bring optimized solutions and maximum benefit to patients."


    Janssen pioneered the advancement of the first innovations in hepatitis C for nearly a decade when it co-developed telaprevir, a first-in-class protease inhibitor used in combination therapy for the treatment of chronic hepatitis C virus. In collaboration with Medivir AB, Janssen subsequently developed and launched the second generation protease inhibitor OLYSIO® (simeprevir), which is approved in countries around the world.


    Today, people living with hepatitis C have a much more diverse range of therapies available following a wave of innovative treatments securing approval. For most, the standard of care for hepatitis C therapy has a duration of 8-12 weeks offering a cure to around 92-100% of people treated.

    AL-335development programdiscontinuehepatitis CJanssenJanssen Sciences Ireland UCJNJ-4178Johnson and JohnsonLawrence M BlattodalasvirOLYSIOprotease inhibitorsimeprevir
    Source : Press Release

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    Ruby Khatun Khatun
    Ruby Khatun Khatun
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