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    • Eli Lilly buys Rs 736...

    Eli Lilly buys Rs 736 Crore stake in gene-silencing drug firm Dicerna

    Medical Dialogues BureauWritten by Medical Dialogues Bureau Published On 2018-10-30T16:43:45+05:30  |  Updated On 30 Oct 2018 4:43 PM IST
    Eli Lilly buys Rs 736 Crore stake in gene-silencing drug firm Dicerna
    Dicerna will receive an upfront payment of $100 million, as well as an equity investment of $100 million at a premium.

    New Delhi: Eli Lilly and Dicerna Pharmaceutical recently announced a global licensing and research collaboration focused on the discovery, development and commercialization of potential new medicines in the areas of cardio-metabolic disease, neurodegeneration and pain. The companies will utilize Dicerna's proprietary GalXC RNAi technology platform to progress new drug targets toward clinical development and commercialization. In addition, the partners will collaborate to move beyond the current technical paradigm in order to generate next-generation oligonucleotide therapeutic agents.

    RNA interference (RNAi) is an emerging new approach to drug discovery, focused on a biologic process in which certain RNA molecules inhibit the expression of disease-causing genes by destroying the messenger RNAs (mRNAs) of those genes. RNAi has the potential to treat diseases by silencing some of the most well-validated, yet previously inaccessible drug targets.

    "At Lilly, we go to where breaking science meets unmet medical needs," said Daniel M. Skovronsky, M.D., Ph.D., Lilly senior vice president and chief scientific officer. "We are excited to collaborate with Dicerna and utilize their RNAi expertise to study targets that up until now have proven to be very technically challenging. RNAi has the potential to treat an array of diseases that are of strategic importance to Lilly. Together with Dicerna, we aim to employ this emerging modality for greater success in drug development."

    "The collaboration with Lilly provides an exceptional opportunity to leverage our proprietary GalXC platform in order to generate new medicines for cardio-metabolic diseases, and to establish a presence in new fields including neurodegeneration and pain," said Douglas M. Fambrough, Ph.D., president and chief executive officer of Dicerna. "Lilly, with its demonstrated leadership in each of these fields, is an ideal partner for extending the range of Dicerna's proprietary GalXC technology, which is designed to silence the expression of disease-driving genes. We are eager and ready to expand and advance our pipeline of innovative GalXC-based therapies, including both proprietary and partnered programs."

    Under the terms of the agreement, Dicerna will receive an upfront payment of $100 million, as well as an equity investment of $100 million at a premium. Dicerna is also eligible to receive up to approximately $350 million per target in development and commercialization milestones, as well as tiered royalties ranging from the mid-single to low-double digits on product sales. Dicerna will work exclusively with Lilly in the neurodegeneration and pain fields, and on select targets in cardio-metabolic diseases. The two companies anticipate collaborating on more than ten targets.

    This transaction is subject to clearance under the Hart-Scott-Rodino Antitrust Improvements Act and other customary closing conditions. The transaction will be reflected in Lilly's reported results and financial guidance according to Generally Accepted Accounting Principles (GAAP). There will be no change to Lilly's 2018 non-GAAP earnings per share guidance as a result of this transaction.

    Read Also: Sanofi, Novo Nordisk Eli Lilly accused of deceptive drug pricing of Insulin

    10 experimental drugsAlexion PharmaAlnylam Pharmacardio-metabolic disordersDicerna PharmaEli Lilygene silencing drugJohnson & Johnsonneuro-degenerative diseasesOnpattroRNA interference

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    Medical Dialogues Bureau
    Medical Dialogues Bureau

      Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers.  Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in. Check out more about our bureau/team here

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