Regeneron drops eye-drug combination as Novartis chases Eylea

Regeneron Pharmaceuticals is dropping plans to develop a new eye drug combination, marking a setback for the U.S. biotech company as Swiss rival Novartis seeks to snatch sales from its existing Eylea medicine.

Results from two mid-stage clinical trials that added nesvacumab to Eylea “did not provide sufficient differentiation to warrant Phase 3 development”, Regeneron said on Monday.

“We knew from the start that it would be difficult to improve on the already high bar set by Eylea,” said the president and chief scientific officer, George Yancopoulos.

Eylea, on which Regeneron has partnered with Bayer, generates annual sales of $5 billion but faces looming competition from an experimental Novartis drug known as RTH258, which has shown advantages over Eylea in clinical trials run by the Swiss group.

Both drugs are designed primarily to treat wet, age-related macular degeneration, where abnormal, leaky blood vessels can cause blindness. The condition affects 20-25 million people worldwide.