Ervaxx, Cardiff University enter collaboration to develop novel 
T-cell and T-cell receptor-based immunotherapeutics targeting 
Dark Antigens™

The new collaboration will support a multi-year research program with Prof. Andrew Sewell's T-cell modulation group at Cardiff University focusing on the discovery and characterization of T-cells and TCRs reactive to cancer-specific antigens and ligands, including Ervaxx' proprietary Dark Antigens™. Ervaxx will fund the program.

The collaboration will also advance exciting new research published earlier this week by the Cardiff University team in Nature Immunology¹, where they identified a T cell clone that recognized and killed multiple different types of human cancer while remaining inert to non-cancerous cells. The T cell clone targets MR1, an MHC class 1-related protein, via an unidentified cancer-specific ligand. These exciting findings, validated in a preclinical model, open the prospect of immunotherapies with broad utility across patients with diverse cancers. This approach into previously unexplored cell surface epitopes complements and extends Ervaxx's exploration of novel cancer-specific antigens.

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Under the agreement, Ervaxx gains an exclusive license to relevant Cardiff University patents claiming T cells and TCRs reactive to cancer-specific antigens. The Company has the right to advance resulting candidate T-cell/TCR-based immunotherapeutics and cancer vaccines through development and commercialization. Cardiff University is eligible to receive milestone payments on any candidates that advance from the discovery of collaboration into clinical development and royalty payments on sales of any products that reach the market.