AbbVie's rheumatoid arthritis drug succeeds in late-stage study

Abbvie Inc said its experimental drug met the main goal of halting the progression of moderate-to-severe rheumatoid arthritis in a late-stage trial.

The drug, upadacitinib, was tested as a monotherapy in patients who have not been treated with chemotherapy agent methotrexate.

Upadacitinib, which belongs to a class of drugs known as JAK inhibitors, also helped improve symptoms of the disease such as swollen joint counts, the company said, adding it plans to submit a U.S. marketing application in the second half of 2018.

AbbVie, whose drug Humira is the market-leading treatment for rheumatoid arthritis, is among drugmakers developing JAK inhibitors, which work by blocking inflammation-causing enzymes known as Janus kinases.